Prevalence of quadruplexes in the human genome

JL Huppert, S Balasubramanian - Nucleic acids research, 2005 - academic.oup.com
Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded
structures called G-quadruplexes. In this paper, we present a working rule to predict which …

G-quadruplexes in promoters throughout the human genome

JL Huppert, S Balasubramanian - Nucleic acids research, 2007 - academic.oup.com
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes.
These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the …

An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation

S Kumari, A Bugaut, JL Huppert… - Nature chemical …, 2007 - nature.com
Guanine-rich nucleic acid sequences can adopt noncanonical four-stranded secondary
structures called guanine (G)-quadruplexes 1 . Bioinformatics analysis suggests that G-…

Structure, location and interactions of G‐quadruplexes

JL Huppert - The FEBS journal, 2010 - Wiley Online Library
Four‐stranded G‐rich DNA structures called G‐quadruplexes have been the subject of
increasing interest recently. Experimental and computational techniques have been used to …

Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH

EP Wright, JL Huppert, ZAE Waller - Nucleic acids research, 2017 - academic.oup.com
i-Motifs are alternative DNA secondary structures formed in cytosine-rich sequences. Particular
examples of these structures, traditionally assumed to be stable only at acidic pH, have …

Direct visualization of G-quadruplexes in DNA using atomic force microscopy

KJ Neaves, JL Huppert, RM Henderson… - Nucleic acids …, 2009 - academic.oup.com
The formation of G-quadruplexes in G-rich regions of DNA is believed to affect DNA
transcription and replication. However, it is currently unclear how this formation occurs in the …

Seven essential questions on G-quadruplexes

SLB König, AC Evans, JL Huppert - 2010 - degruyter.com
The helical duplex architecture of DNA was discovered by Francis Crick and James Watson
in 1951 and is well known and understood. However, nucleic acids can also adopt …

Distance-dependent duplex DNA destabilization proximal to G-quadruplex/ i -motif sequences

SLB König, JL Huppert, RKO Sigel… - Nucleic acids …, 2013 - academic.oup.com
G-quadruplexes and i -motifs are complementary examples of non-canonical nucleic acid
substructure conformations. G-quadruplex thermodynamic stability has been extensively …

Thermodynamic prediction of RNA–DNA duplex-forming regions in the human genome

JL Huppert - Molecular BioSystems, 2008 - pubs.rsc.org
RNA–DNA hybrids can form in a physiological context, especially as a consequence of
transcription, accompanied by the separation of the second strand of DNA. These structures …

What do the British public think of inequality in health, wealth, and power?

D Howarth, TM Marteau, AP Coutts, JL Huppert… - Social Science & …, 2019 - Elsevier
Despite the importance of public opinion for policy formation and the political salience of
inequality, the public's views about the desirability of equality, not only in health but also in …