A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

…, RJF Loos, I Barroso, NJ Wareham, F Karpe, KR Owen… - Science, 2007 - science.org
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

…, CJ Groves, LW Harries, JL Marchini, KR Owen… - Science, 2007 - science.org
The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

…, AD Morris, N Narisu, P Nilsson, KR Owen… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

…, MA Morken, N Narisu, P Nilsson, KR Owen… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Common variants near MC4R are associated with fat mass, weight and risk of obesity

…, MJ Neville, AC Nica, KK Ong, S O'Rahilly, KR Owen… - Nature …, 2008 - nature.com
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …

Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the …

AL Gloyn, MN Weedon, KR Owen, MJ Turner… - Diabetes, 2003 - Am Diabetes Assoc
The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1)
and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (K …

An expanded genome-wide association study of type 2 diabetes in Europeans

…, DJ Hunter, P Kraft, Q Sun, S Edkins, KR Owen… - Diabetes, 2017 - Am Diabetes Assoc
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum,
we conducted a meta-analysis of genome-wide association data from 26,676 T2D case …

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

…, C Navarro, MM Noethen, NN Oskolkov, KR Owen… - Nature …, 2015 - nature.com
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and
57,574 controls of European ancestry. We identified 49 distinct association signals at these …

[HTML][HTML] Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

…, E Zeggini, NW Rayner, B Shields, KR Owen… - PLoS …, 2006 - journals.plos.org
Background A limited number of studies have assessed the risk of common diseases when
combining information from several predisposing polymorphisms. In most cases, individual …

Diagnosis and management of maturity onset diabetes of the young (MODY)

G Thanabalasingham, KR Owen - Bmj, 2011 - bmj.com
CLINICAL REVIEW Page 1 Diagnosis and management of maturity onset diabetes of the
young (MODY) Gaya Thanabalasingham clinical research fellow1 2, Katharine R Owen