Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …

Background Early, goal-directed therapy (EGDT) is recommended in international guidelines
for the resuscitation of patients presenting with early septic shock. However, adoption has …

Context Extracorporeal membrane oxygenation (ECMO) can support gas exchange in
patients with severe acute respiratory distress syndrome (ARDS), but its role has remained …

Objective: Critical care represents a large percentage of healthcare spending in developed
countries. Yet, little is known regarding international variation in critical care services. We …

Background Uncertainty exists about the most effective route for delivery of early nutritional
support in critically ill adults. We hypothesized that delivery through the parenteral route is …

Risk stratification is essential for both clinical risk prediction and comparative audit. There
are a variety of risk stratification tools available for use in major noncardiac surgery, but their …

Objective: To determine the effect of different intensivist staffing models on clinical outcomes
for critically ill patients. Data Sources: A sensitive search of electronic databases and hand-…

Rationale: The United States has seven times as many intensive care unit (ICU) beds per
capita as the United Kingdom; the effect on care of critically ill patients is unknown. Objectives: …

Rationale: Survivors of critical illness experience significant morbidity, but the impact of
surviving the intensive care unit (ICU) has not been quantified comprehensively at a population …

Importance Vasopressors are commonly administered to intensive care unit (ICU) patients
to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, …