Fluorescence microscopy is one of the most powerful tools for elucidating the cellular
functions of proteins and other molecules. In many cases, the function of a molecule can be …

Objective To describe, for the first time, distribution (by geography, age, sex) and time trends
in burn injury in England and Wales over the period that the international Burn Injury …

To study the fusion and separation of endocytic compartments, we have used digital image
analysis to quantify the accumulation of fluorescent ligands in endosomes during continuous …

Endocytosed proteins are sorted in early endosomes to be recycled to the plasma membrane
or transported further into the degradative pathway. We studied the role of endosomes …

Optical microscopy, when applied to living animals, provides a powerful means of studying
cell biology in the most physiologically relevant setting. The ability of two-photon microscopy …

Background Continued improvement in all aspects of the management of thermal injury has
resulted in marked improvements in the traditionally reported outcome of mortality. This has …

The scale of biological microscopy has increased dramatically over the past ten years, with
the development of new modalities supporting collection of high-resolution fluorescence …

Rab10, a protein originally isolated from Madin-Darby Canine Kidney (MDCK) epithelial
cells, belongs to a family of Rab proteins that includes Rab8 and Rab13. Although both Rab8 …

Apoptosis is an important mode of cell death under both physiological and pathophysiological
conditions. Numerous techniques are available for the study and quantitation of apoptosis …

Major histocompatibility complex (MHC) class II antigens are expressed on human foreskin
keratinocytes (HFKs) following exposure to interferon gamma. The expression of MHC class …