Mycobacterium tuberculosis (MTb) kills approximately 2 million people each year. MTb must
drive host tissue destruction to disseminate and also to cause pulmonary cavitation. Matrix …

Aims While conventional therapy is curative for most patients with high grade lymphomas,
there is considerable heterogeneity in this diagnosis, with scope to refine treatment according …

Antagonistic coevolution between hosts and parasites is probably ubiquitous. However, very
little is known of the genetic changes associated with parasite infectivity evolution during …

We still know very little about how the environment influences coevolutionary dynamics.
Here, we investigated both theoretically and empirically how nutrient availability affects the …

The value of genome-wide over targeted driver analyses for predicting clinical outcomes of
cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic …

Pulmonary cavitation is vital to the persistence and spread of Mycobacterium tuberculosis (MTb),
but mechanisms underlying this lung destruction are poorly understood. Fibrillar type I …

The transformation of chronic lymphocytic leukemia (CLL) to high-grade B-cell lymphoma is
known as Richter syndrome (RS), a rare event with dismal prognosis. In this study, we …

Background The dynamics of antagonistic host-parasite coevolution are believed to be crucially
dependent on the rate of migration between populations. We addressed how the rate of …

Coevolution commonly occurs in spatially heterogeneous environments, resulting in variable
selection pressures acting on coevolving species. Dispersal across such environments is …

Introduction Plasma cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) genotyping
in Diffuse Large B-cell Lymphoma (DLBCL) holds great promise for early detection and …