Purpose It is uncertain whether modest benefits from adjuvant chemotherapy in stage II
colorectal cancer justify the toxicity, cost, and inconvenience. We investigated the usefulness of …

PURPOSE Neoadjuvant chemotherapy (NAC) has potential advantages over standard
postoperative chemotherapy for locally advanced colon cancer but requires formal evaluation. …

… Gray, Philip Quirke, Kelly Handley, Margarita Lopatin, Laura Magill, Frederick L. Baehner,
Claire Beaumont, Kim M. Clark-Langone, Carl N. … University of Oxford, Oxford; Kelly …

The Lancet Commission on Global Surgery1 identified that 313 million surgical procedures
are performed worldwide each year. Little is known about the quality of surgery globally …

Objective To determine the clinical effectiveness of wound edge protection devices in
reducing surgical site infection after abdominal surgery. Design Multicentre observer blinded …

Background Radical surgery via total mesorectal excision might not be the optimal first-line
treatment for early-stage rectal cancer. An organ-preserving strategy with selective total …

Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine
pathology slides in colorectal cancer (CRC). However, current approaches rely on convolutional …

Background Evidence suggests an important role for gut-microbiota dysbiosis in the
development of rheumatoid arthritis (RA). The link between changes in gut bacteria and the …

Introduction Total mesorectal excision (TME) is the highly effective standard treatment for
rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk …

Background Malnutrition represents a key priority for global health policy, yet the impact of
nutritional state on cancer surgery worldwide remains poorly described. We aimed to analyse …