We have used the nested polymerase chain reaction (PCR) combined with fluorescence-activated
cell sorting to define sites of latency of human cytomegalovirus (HCMV) in the …

“The more accurately to observe the progress of the infection, I selected a healthy boy about
eight years old for the purpose of inoculation with the cowpox. The matter was taken from …

Little is known about innate immunity to bacteria after birth in the hitherto sterile fetal
intestine. Breast-feeding has long been associated with a lower incidence of gastrointestinal …

The inhibitory leukocyte Ig-like receptor 1 (LIR-1, also known as ILT2, CD85j, or LILRB1)
was identified by its high affinity for the human CMV (HCMV) MHC class I homolog gpUL18. …

The top 20 policy and research priorities for conditions such as diabetes, stroke and heart
disease.

The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits
natural killer (NK) cell–mediated lysis by interacting with CD94/NKG2A receptors. Surface …

Dendritic cells (DCs) play a pivotal role in the generation of virus-specific cytotoxic T-cell
responses, but some viruses can render DCs inefficient in stimulating T cells. We studied …

The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL) response
is important in the clearance of viral infections in humans. After influenza A infection, a …

Human cytomegalovirus (HCMV) exploits a range of strategies to evade and modulate the
immune response. Its capacity to down-regulate MHC I expression was anticipated to render …

CTLs specific for high-risk human papillomaviruses (HPVs) have recently been found in the
peripheral blood of cervical cancer patients. Although cell-mediated immunity is thought to …