Repression of osteocyte Wnt/β‐catenin signaling is an early event in the progression of renal osteodystrophy

…, W Tang, LM dos Reis, S Ryan, L Phillips… - Journal of Bone and …, 2012 - academic.oup.com
Chronic kidney disease–mineral bone disorder (CKD‐MBD) is defined by abnormalities in
mineral and hormone metabolism, bone histomorphometric changes, and/or the presence of …

Cochlear implantation in children under the age of two—what do the outcomes show us?

…, MS Quevedo, J Martin, WS Dieler, L Phillips - International journal of …, 2004 - Elsevier
Objective: Literature that discusses the benefits of cochlear implantation (CI) in children
under the age of two is limited. Previous concerns about surgical risk have been raised and …

[HTML][HTML] A systematic review and meta-analysis of suicidality in autistic and possibly autistic people without co-occurring intellectual disability

V Newell, L Phillips, C Jones, E Townsend, C Richards… - Molecular autism, 2023 - Springer
Background Suicidality is highly prevalent in autistic people without co-occurring intellectual
disabilities, and high autistic traits are found in adults who have attempted suicide. However…

Npt2b deletion attenuates hyperphosphatemia associated with CKD

…, W Song, J Boulanger, S Ryan, L Phillips… - Journal of the …, 2012 - journals.lww.com
The incidence of cardiovascular events and mortality strongly correlates with serum phosphate
in individuals with CKD. The Npt2b transporter contributes to maintaining phosphate …

[HTML][HTML] Mechanisms and regulation of IL-22-mediated intestinal epithelial homeostasis and repair

…, S Wilson, V Pivorunas, J Karman, L Phillips… - Life Sciences, 2021 - Elsevier
Aims Ulcerative colitis and Crohn's disease, collectively known as inflammatory bowel
disease (IBD), are chronic inflammatory disorders of the intestine for which key elements in …

Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis

…, J Karman, TL Carr, JB Wetter, L Phillips… - Science …, 2022 - science.org
Immune cells are fundamental regulators of extracellular matrix (ECM) production by fibroblasts
and have important roles in determining extent of fibrosis in response to inflammation. …

[HTML][HTML] Anti-microRNA-21 therapy on top of ACE inhibition delays renal failure in Alport syndrome mouse models

…, J Boulanger, F Craciun, EY Xu, Y Zhang, L Phillips… - Cells, 2022 - mdpi.com
Col4a3 −/− Alport mice serve as an animal model for renal fibrosis. MicroRNA-21 (miR-21)
expression has been shown to be increased in the kidneys of Alport syndrome patients. Here, …

[HTML][HTML] Antisense oligonucleotide-mediated suppression of muscle glycogen synthase 1 synthesis as an approach for substrate reduction therapy of Pompe disease

…, KM Taylor, RJ Moreland, RK Scheule, L Phillips… - … therapy-Nucleic acids, 2014 - cell.com
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase
(GAA; EC 3.2.1.20) and the resultant progressive lysosomal accumulation of glycogen …

Systemic delivery of a Peptide-linked morpholino oligonucleotide neutralizes mutant RNA toxicity in a mouse model of myotonic dystrophy

…, IH Wu, T Weeden, CA Nelson, L Phillips… - nucleic acid …, 2013 - liebertpub.com
Expansions of CUG trinucleotide sequences in RNA transcripts provide the basis for toxic
RNA gain-of-function that leads to detrimental changes in RNA metabolism. A CTG repeat …

[HTML][HTML] Optimized culture conditions for improved growth and functional differentiation of mouse and human colon organoids

…, H Knight, L Patnaude, X Wu, L Phillips… - Frontiers in …, 2021 - frontiersin.org
Background & Aims Diligent side-by-side comparisons of how different methodologies affect
growth efficiency and quality of intestinal colonoids have not been performed leaving a gap …