Pregnancy is a unique immunological state in which a balance of immune tolerance and
suppression is needed to protect the fetus without compromising the mother. It has long been …

There has been a surge in studies implicating a role of vaginal microbiota in spontaneous
preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a …

Pregnancy is a complex immunological state in which a bias towards T helper 2 (Th2)
protects the fetus. Evidence suggests that proinflammatory cytokines increase the risk of poor …

Preterm birth is a global health concern and continues to contribute to substantial neonatal
morbidity and mortality despite advances in obstetric and neonatal care. The underlying …

Intrauterine inflammation is recognized as a key mediator of both normal and preterm birth
but is also associated with neonatal neurological injury. Lipopolysaccharide (LPS) is often …

Pregnancy is characterized by a complex interplay of inflammatory events regulated by both
the innate and acquired immune systems. Similarly, parturition can be viewed as the …

Preterm birth (PTB) is the leading cause of infant death and disability worldwide. The onset
of preterm uterine contractions is preceded by asymptomatic cervical remodelling and …

Preterm birth occurs in 10–12% of pregnancies and is the primary cause of neonatal mortality
and morbidity. Tocolytic therapies have long been the focus for the prevention of preterm …

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of
death in children under 5 years of age. Here we describe direct on-swab metabolic profiling …

Background Small-for-gestational-age fetuses (SGA) (birthweight <10th centile) are at high
risk for stillbirth or long-term adverse outcomes. Here, we investigate the ability of circulating …