Hypersensitivity reactions to HIV therapy

M Chaponda, M Pirmohamed - British journal of clinical …, 2011 - Wiley Online Library
Many drugs used for the treatment of HIV disease (including the associated opportunistic
infections) can cause drug hypersensitivity reactions, which vary in severity, clinical …

[HTML][HTML] Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis

AJ Stockdale, M Chaponda, A Beloukas… - The Lancet global …, 2017 - thelancet.com
Background Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent
infection in people with chronic hepatitis B, leading to accelerated progression of liver …

Systematic review of the prevalence of psychiatric illness and sleep disturbance as co-morbidities of HIV infection in the UK

M Chaponda, N Aldhouse, M Kroes… - … journal of STD & …, 2018 - journals.sagepub.com
Psychiatric illness and sleeping disorders are important co-morbidities of human immunodeficiency
virus (HIV) infection, which impact both the individual and antiretroviral therapy (ART…

Bacteraemia and Mortality Among Adult Medical Admissions in Malawi–Predominance of Non-typhi Salmonellae andStreptococcus pneumoniae

…, AL Walsh, M Chaponda, D Soko, M Mbvwinji… - Journal of Infection, 2001 - Elsevier
Objectives: The high seroprevalence of HIV in Malawi might be expected to alter the pattern
of pathogens isolated from bacteraemic patients. We aimed to describe the frequency and …

Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population

DF Carr, M Chaponda, AL Jorgensen… - Clinical Infectious …, 2013 - academic.oup.com
Background. The nonnucleoside reverse transcriptase inhibitor nevirapine is the cornerstone
of treatment for human immunodeficiency virus (HIV) in many sub-Saharan African …

Bacterial meningitis in Malawian adults: pneumococcal disease is common, severe, and seasonal

SB Gordon, AL Walsh, M Chaponda… - Clinical Infectious …, 2000 - academic.oup.com
We prospectively collected laboratory details and outcome data on all patients with
laboratory-confirmed cases of meningitis that presented to our unit in Blantyre, Malawi, from 1 April …

[HTML][HTML] High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia

…, DE Norris, M Mulenga, M Chaponda, M Muleba… - Malaria journal, 2014 - Springer
Background Malaria control interventions have been scaled-up in Zambia in conjunction
with a malaria surveillance system. Although substantial progress has been achieved in …

[HTML][HTML] Malaria knowledge and bed net use in three transmission settings in southern Africa

…, J Lupiya, JC Stevenson, S Mharakurwa, M Chaponda… - Malaria Journal, 2018 - Springer
Background Insecticide-treated nets (ITNs) reduce malaria morbidity and mortality in endemic
areas. Despite increasing availability, the use of ITNs remains limited in some settings. …

[HTML][HTML] Individual and household level risk factors associated with malaria in Nchelenge District, a region with perennial transmission: a serial cross-sectional study …

…, M Chaponda, TM Shields, J Sichivula, M Muleba… - PLoS …, 2016 - journals.plos.org
Background The scale-up of malaria control interventions has resulted in substantial declines
in transmission in some but not all regions of sub-Saharan Africa. Understanding factors …

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

DF Carr, S Bourgeois, M Chaponda… - Journal of …, 2017 - academic.oup.com
Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%–10%
of patients, including hepatotoxicity, maculopapular exanthema, Stevens–Johnson …