1.2. Definitions Ulcerative colitis [UC] is a chronic inflammatory condition that causes continuous
mucosal inflammation of the colon, usually without granulomas on biopsy. It affects the …

This paper is the first in a series of two publications relating to the European Crohn’s and
Colitis Organisation [ECCO] evidence-based consensus on the diagnosis and management of …

Since Tysk et al's pioneering analysis of the Swedish twin registry, twin and family studies
continue to support a strong genetic basis of the inflammatory bowel diseases. The coefficient …

… Marcus Harbord † … Marcus Harbord, Vito Annese, Stephan R. Vavricka, Matthieu Allez,
Manuel Barreiro-de Acosta, Kirsten Muri Boberg, Johan Burisch, Martine De Vos, Anne-Marie …

… In the PURSUIT-M trial, 464 patients showing evidence of response to induction therapy …
Specifically for those patients entering PURSUIT-M receiving corticosteroids, 34.4% of those …

Background This European Crohn’s and Colitis Organisation [ECCO] topical review focuses
on the transition of adolescents with inflammatory bowel disease [IBD] from child-centred to …

Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …

The relationship between severe myoclonic epilepsy of infancy (SMEI or Dravet syndrome)
and the related syndrome SMEI-borderland (SMEB) with mutations in the sodium channel …

Background The cause of Crohn's disease has not been mechanistically proven. We tested
the hypothesis that the disease is a form of immunodeficiency caused by impaired innate …

X-linked West syndrome, also called "X-linked infantile spasms" (ISSX), is characterized by
early-onset generalized seizures, hypsarrhythmia, and mental retardation. Recently, we have …