Osteoporosis is a major cause of morbidity and mortality through its association with age-related
fractures. Although most effort in fracture prevention has been directed at retarding the …

Purpose This study was conducted in order to systematically review the costs of hip fractures
globally and identify drivers of differences in costs. Methods A systematic review was …

An evidence‐based clinical guideline for the diagnosis and management of Paget's disease
of bone (PDB) was developed using GRADE methodology, by a Guideline Development …

Objective. To identify pre-operative predictors of patient-reported outcomes of primary total
knee replacement (TKR) surgery. Methods. The Elective Orthopaedic Centre database is a …

Objective: To investigate whether exposure to high maternal concentrations of 25 (OH)-vitamin
D in pregnancy poses any risk to the child. Design: Prospective study. Setting: Princess …

Objectives Data on the incidence of symptomatic osteoarthritis (OA) are scarce. We estimated
incidence of clinical hip, knee and hand OA, and studied the effect of prevalent OA on joint-…

Objectives: To describe the natural history of subchondral bone marrow lesions (BMLs) in a
sample of subjects with knee osteoarthritis (OA) or at risk of developing it. Additionally, to …

Using a large cohort of hip fracture patients, we estimated hospital costs to be £14,163 and £2139
in the first and second year following fracture, respectively. Second hip and non-hip …

Background Maternal vitamin D status has been associated with bone mass of offspring in
many, but not all, observational studies. However, maternal vitamin D repletion during …

A growing body of evidence has consistently shown a correlation between obesity and chronic
subclinical inflammation. It is unclear whether the size of specific adipose depots is more …