Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the
human motor system. In this Seminar, we summarise current concepts about the origin of the …

This article presents the revised consensus criteria for the diagnosis of frontotemporal
dysfunction in amyotrophic lateral sclerosis (ALS) based on an international research workshop …

Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS)
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …

Background Concerns regarding potential neurological complications of COVID-19 are being
increasingly reported, primarily in small series. Larger studies have been limited by both …

A 2D Gabor filter can be realized as a sinusoidal plane wave of some frequency and
orientation within a two dimensional Gaussian envelope. Its spatial extent, frequency and …

Microglial activation is implicated in the pathogenesis of ALS and can be detected in animal
models of the disease that demonstrate increased survival when treated with anti-…

… Turner o, Yoshikazu Ugawa p, Leonard H. van den Berg q, Renato Verdugo r, Steven Vucic
… signs for at least 4 years after disease onset (Turner et al., 2020). These patients have a …

Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a
number of neurological conditions compared with healthy controls (HC) and is a candidate …

Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive
disorder. After half a century of trials, only one drug with modest disease-modifying potency—…

Objective: To test blood and CSF neurofilament light chain (NfL) levels in relation to disease
progression and survival in amyotrophic lateral sclerosis (ALS). Methods: Using an …