Early management of respiratory muscle failure using mechanical ventilation and high-dose
abatacept with CD86 receptor occupancy monitoring combined with ruxolitinib may be …

Background : Ibrutinib has revolutionized treatment for several B-cell malignancies. However,
a recent clinical trial where ibrutinib was used in a front-line setting showed increased …

BACKGROUND: Immune checkpoint inhibitors (ICIs) are approved for multiple cancers but
can result in ICI-associated myocarditis, an infrequent but life-threatening condition. …

Immune checkpoint inhibitors (ICI) have transformed the therapeutic landscape in oncology.
However, ICI can induce uncommon life-threatening autoimmune T-cell-mediated …

Background Long QT syndrome (LQTS) can cause the potentially fatal ventricular tachycardia
torsades de pointes (TdP). QT interval corrected for heart rate (QTc) is shorter in men than …

Background Myocarditis is a dreaded and unpredictable complication of immune checkpoint
inhibitors (ICI). We sought to determine whether routinely measured biomarkers could be …

Immune-checkpoint inhibitors (ICI) have revolutionized cancer therapy but are associated
with infrequent but lethal myocarditis, for which management remains uncertain. Abatacept, a …

Background Abiraterone and enzalutamide are recently-approved androgen deprivation
therapies (ADTs) for metastatic prostate cancer, with unknown cardiac safety profiles. …

KRAS mutation, one of the most common molecular alterations observed in adult carcinomas,
was reported to activate the anti-oxidant program driven by the transcription factor NRF2 (…

Immune-checkpoint inhibitors (ICI) have profoundly improved the prognosis of cancer patients
but are associated with life-threatening myocarditis (incidence≤ 1%).(1) The diagnosis of …