User profiles for Mark B Pepys
Mark PepysVerified email at ucl.ac.uk Cited by 75961 |
[HTML][HTML] C-reactive protein: a critical update
MB Pepys, GM Hirschfield - The Journal of clinical …, 2003 - Am Soc Clin Investig
In the mid 1990s, immunoassays for C-reactive protein (CRP), with greater sensitivity than
those previously in routine use, revealed that increased CRP values, even within the range …
those previously in routine use, revealed that increased CRP values, even within the range …
[HTML][HTML] C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
…, A Rumley, GDO Lowe, MB Pepys… - New England journal …, 2004 - Mass Medical Soc
Background C-reactive protein is an inflammatory marker believed to be of value in the
prediction of coronary events. We report data from a large study of C-reactive protein and other …
prediction of coronary events. We report data from a large study of C-reactive protein and other …
[HTML][HTML] The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina
…, RL Grillo, AG Rebuzzi, MB Pepys… - New England journal …, 1994 - Mass Medical Soc
Background The pathogenesis of unstable angina is poorly understood, and predicting the
prognosis is problematic. Evidence suggests that there may be active inflammation, possibly …
prognosis is problematic. Evidence suggests that there may be active inflammation, possibly …
C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA …
…, H Löwel, A Döring, WL Hutchinson, MB Pepys - Circulation, 1999 - Am Heart Assoc
Background—Inflammatory reactions in coronary plaques play an important role in the
pathogenesis of acute atherothrombotic events; inflammation elsewhere is also associated with …
pathogenesis of acute atherothrombotic events; inflammation elsewhere is also associated with …
Common core structure of amyloid fibrils by synchrotron X-ray diffraction
Tissue deposition of normally soluble proteins as insoluble amyloid fibrils is associated with
serious diseases including the systemic amyloidoses, maturity onset diabetes, Alzheimer’s …
serious diseases including the systemic amyloidoses, maturity onset diabetes, Alzheimer’s …
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
…, A Thomson, P Appleby, JR Gallimore, MB Pepys - Bmj, 2000 - bmj.com
Objective: To assess associations between baseline values of four different circulating
markers of inflammation and future risk of coronary heart disease, potential triggers of systemic …
markers of inflammation and future risk of coronary heart disease, potential triggers of systemic …
Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis
Tissue deposition of soluble proteins as amyloid fibrils underlies a range of fatal diseases.
The two naturally occurring human lysozyme variants are both amyloidogenic, and are shown …
The two naturally occurring human lysozyme variants are both amyloidogenic, and are shown …
[PDF][PDF] The physiological structure of human C-reactive protein and its complex with phosphocholine
D Thompson, MB Pepys, SP Wood - Structure, 1999 - cell.com
Background: Human C-reactive protein (CRP) is the classical acute phase reactant, the
circulating concentration of which rises rapidly and extensively in a cytokine-mediated response …
circulating concentration of which rises rapidly and extensively in a cytokine-mediated response …
C-reactive protein fifty years on
MB Pepys - The Lancet, 1981 - Elsevier
The discovery of C-reactive protein (CRP) half a century ago led to the description of the
acute-phase reaction which is a fundamental response of the body to injury. Recent work on the …
acute-phase reaction which is a fundamental response of the body to injury. Recent work on the …
Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease.
DM Vigushin, MB Pepys… - The Journal of clinical …, 1993 - Am Soc Clin Investig
Plasma and whole-body turnover studies of human C-reactive protein (CRP), isolated from
a single normal healthy donor and labeled with 125I, were undertaken in 8 healthy control …
a single normal healthy donor and labeled with 125I, were undertaken in 8 healthy control …