[HTML][HTML] Tip60 is a nuclear hormone receptor coactivator

ME Brady, DM Ozanne, L Gaughan, I Waite… - Journal of Biological …, 1999 - ASBMB
The androgen receptor (AR) is a member of the nuclear hormone receptor superfamily.
Recent work in this field has been focused upon defining the mechanisms of transcriptional …

Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development

…, VJ Gnanapragasam, PB Mehta, IR Logan, ME Brady… - Oncogene, 2003 - nature.com
Prostate cancer (CaP) is initially androgen sensitive and responsive to hormone ablation
therapy. However, cancer growth recurs despite androgen deprivation in the majority of cases …

Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin

DM Ozanne, ME Brady, S Cook… - Molecular …, 2000 - academic.oup.com
The human androgen receptor (hAR) is a ligand-dependent transcription factor responsible
for the development of the male phenotype. The mechanism whereby nuclear translocation …

Frailty is independently associated with worse health-related quality of life in chronic kidney disease: a secondary analysis of the Frailty Assessment in Chronic Kidney …

…, N Pendleton, S Mitra, ME Brady… - Clinical kidney …, 2020 - academic.oup.com
Background Understanding how frailty affects health-related quality of life (HRQOL) in those
with chronic kidney disease (CKD) could assist in the development of management …

[HTML][HTML] Tip60 is a co-activator specific for class I nuclear hormone receptors

L Gaughan, ME Brady, S Cook, DE Neal… - Journal of Biological …, 2001 - ASBMB
The nuclear hormone receptor superfamily is composed of a group of hormone-dependent
transcription factors that play prominent roles in homeostatic events in vertebrates. A …

[HTML][HTML] Home-based exercise for people living with frailty and chronic kidney disease: a mixed-methods pilot randomised controlled trial

…, KW Finlayson, N Pendleton, S Mitra, ME Brady… - PLoS …, 2021 - journals.plos.org
Background Frailty is associated with adverse health outcomes in people with chronic
kidney disease (CKD). Evidence supporting targeted interventions is needed. This pilot …

[HTML][HTML] Implementation of a frailty screening programme and Geriatric Assessment Service in a nephrology centre: a quality improvement project

…, L Ebah, S Mitra, AP Dhaygude, ME Brady - Journal of …, 2021 - Springer
Introduction The aims of this quality improvement project were to: (1) proactively identify
people living with frailty and CKD; (2) introduce a practical assessment, using the principles of …

[HTML][HTML] Distinguishing active from quiescent disease in ANCA-associated vasculitis using attenuated total reflection Fourier-transform infrared spectroscopy

…, CLM Morais, KMG Lima, DLD Freitas, ME Brady… - Scientific Reports, 2021 - nature.com
The current lack of a reliable biomarker of disease activity in anti-neutrophil cytoplasmic
autoantibody (ANCA) associated vasculitis poses a significant clinical unmet need when …

The EX-FRAIL CKD trial: a study protocol for a pilot randomised controlled trial of a home-based EXercise programme for pre-frail and FRAIL, older adults with Chronic …

…, KW Finlayson, N Pendleton, S Mitra, ME Brady… - BMJ open, 2020 - bmjopen.bmj.com
Introduction Frailty is highly prevalent in adults with chronic kidney disease (CKD) and is
associated with adverse health outcomes including falls, poorer health-related quality of life (…

[HTML][HTML] Automated computational detection of disease activity in ANCA-associated glomerulonephritis using Raman spectroscopy: a pilot study

AD Morris, DLD Freitas, KMG Lima, L Floyd, ME Brady… - Molecules, 2022 - mdpi.com
Biospectroscopy offers the ability to simultaneously identify key biochemical changes in tissue
associated with a given pathological state to facilitate biomarker extraction and automated …