Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as
a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …

Background Malignant pleural effusion affects more than 750,000 persons each year across
Europe and the United States. Pleurodesis with the administration of talc in hospitalized …

We report baseline results of a community-based, targeted, low-dose CT (LDCT) lung cancer
screening pilot in deprived areas of Manchester. Ever smokers, aged 55–74 years, were …

Thoracic ultrasound is increasingly considered to be an essential tool for the pulmonologist.
It is used in diverse clinical scenarios, including as an adjunct to clinical decision making for …

For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive
up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. …

Conservative management can be considered for the treatment of minimally symptomatic (ie,
no significant pain or breathlessness and no physiological compromise) or asymptomatic …

Importance Malignant pleural effusion (MPE) is challenging to manage. Talc pleurodesis is
a common and effective treatment. There are no reliable data, however, regarding the …

Patients undergoing major cancer interventions such as major surgical resection, chemotherapy,
radiotherapy, and immunotherapy are prone to the adverse effects of their cancer, as …