… Michael G Hanna Jr was responsible for the preclinical concepts that led to this clinical trial,
and developed the study design with Herbert Pinedo. Michael G Hanna also provided the …

Background The mitochondrial myopathies typically affect many organ systems and are
associated with mutations in mitochondrial DNA (mtDNA) that are maternally inherited. However, …

Background The genetic basis of most common forms of human paroxysmal disorders of the
central nervous system, such as epilepsy, remains unidentified. Several animal models of …

Background A substantial impediment to progress in trials of new therapies in neuromuscular
disorders is the absence of responsive outcome measures that correlate with patient …

PURPOSE: A randomized phase III clinical trial of adjuvant active specific immunotherapy (ASI)
with an autologous tumor cell–bacillus Calmette-Guérin (BCG) vaccine was conducted …

PURPOSE Patients with colon or rectal cancer were entered onto a prospectively randomized,
controlled clinical trial of active specific immunotherapy (ASI) with an autologous tumor …

Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the outer …

The molecular basis of idiopathic generalized epilepsy remains poorly understood. Absence
epilepsy with 3 Hz spike–wave EEG is one of the most common human epilepsies, and is …

Background Population-based studies suggest the m.3243A>G mutation in MTTL1 is the
most common disease-causing mtDNA mutation, with a carrier rate of 1 in 400 people. The m.…

Periodic paralyses (PPs) are rare neuromuscular disorders caused by mutations in skeletal
muscle sodium, calcium, and potassium channel genes. PPs include hypokalemic paralysis, …