Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

The amyloid cascade hypothesis of Alzheimer’s disease (AD) is testable: it implies that
interference with Aβ aggregation and plaque formation may be therapeutically useful. Aβ42 …

Background A large number of SCN5A variants have been reported to underlie Brugada
syndrome (BrS). However, the evidence supporting individual variants is highly heterogeneous. …

There has been significant progress in the prevention of sudden cardiac death in repaired
tetralogy of Fallot (rTOF). Contemporary cohorts report greater survival attributable to …

The identification of a pathogenic SCN5A variant confers an increased risk of conduction
defects and ventricular arrhythmias (VA) in Brugada syndrome (BrS). However, specific aspects …

Background Catheter ablation of ventricular tachycardia (VT) is associated with potential
major complications, including mortality. The risk of acute complications in patients with …

Background Very high power short duration (vHPSD) radiofrequency ablation (RFA) may
reduce ablation times and improve patient tolerability, permitting pulmonary vein isolation (PVI) …

Background Intracardiac echocardiography (ICE) represents a valuable image integration
technique, with the unique advantage of dynamic real-time scar characterization. Objectives …

Transverse (t)-tubules ensure a uniform rise in calcium (Ca 2+ ) and thus contraction in
cardiac cells. Though more extensively studied in the ventricle, t-tubules also play a key role in …

Background Large animal models play an important role in our understanding of the
pathophysiology of atrial fibrillation (AF). Our aim was to determine whether prospectively collected …