INTRODUCTION Human skin provides vital protection from water loss and from external insult
through structural adaptations and interplay with the innate and adaptive immune systems…

… Rajan, JAA Langtry, Generalized exacerbation of psoriasis associated with imiquimod
cream treatment of superficial basal cell carcinomas, Clinical and Experimental Dermatology, …

Frontotemporal dementia and amyotrophic lateral sclerosis are clinically and pathologically
overlapping disorders with shared genetic causes. We previously identified a disease locus …

Background Pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence
base for treatment. Objective We sought to estimate the effectiveness of topical therapies …

Checkpoint inhibitors (CPIs) are monoclonal antibodies which, by disrupting interactions of
immune checkpoint molecules with their ligands, block regulatory immune signals otherwise …

Individuals with germline mutations in the tumour-suppressor gene CYLD are at high risk of
developing disfiguring cutaneous appendageal tumours, the defining tumour being the …

CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important roles in immunity
and cancer. Complete CYLD ablation, truncation and expression of alternate isoforms, …

Cylindroma is a rare skin tumour that is inherited in several skin-tumour syndromes caused
by germline mutations in the tumour suppressor gene, CYLD. In this Review, we provide …

From the first report in 1969 to the present day, diagnosis of eccrine porocarcinoma, also
known simply as porocarcinoma (PC), remains a challenge. This review presents a concise …

Objectives To comprehensively ascertain the extent and severity of clinical features in affected
individuals from 2 large families with proven heterozygous mutations in theCYLDlocus …