Background. The number of elderly patients with chronic kidney disease (CKD) stage 5 is
steadily increasing. Evidence is needed to inform decision-making for or against dialysis, …

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement
plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 …

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline
on the Evaluation and Management of Candidates for Kidney Transplantation is intended to …

Background: It is often believed that patients with advanced chronic kidney disease (CKD)
stage 4–5 have few symptoms, and that dying with renal disease is relatively symptom-free. …

Background The complement system has a critical role in both the innate and the adaptive
immune responses. In humans, C3 exists as two main allotypes, F (fast) and S (slow), which …

Tubulointerstitial inflammation and progressive fibrosis are common pathways that lead to
kidney failure in proteinuric nephropathies. Activation of the complement system has been …

Tubulointerstitial fibrosis is a common consequence of a diverse range of kidney diseases
that lead to end-stage renal failure. The degree of fibrosis is related to leukocyte infiltration. …

Results Seventy-four patients (mean age, 81±6.8 years) were recruited; 49 died during
follow-up. Average trajectories showed moderate symptom distress and health-related concerns, …

Urinary tract infection is one of the commonest infections to affect humans. Uncomplicated
infections occur most commonly in otherwise healthy women when uropathogenic bacteria, …

Complement C3 produced within the kidney may be an important mediator of local inflammatory
and immunological injury. The overall level of renal C3 production and consequently its …