Writers of complex storage applications such as distributed file systems and databases are
faced with the challenges of building complex abstractions over simple storage devices like …

Importance Patients with septic shock undergo adrenergic stress, which affects cardiac,
immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects …

Singularity is a research project in Microsoft Research that started with the question: what
would a software platform look like if it was designed from scratch with the primary goal of …

Background The role of tracheostomy in coronavirus disease 2019 (COVID-19) is unclear,
with several consensus guidelines advising against this practice. We developed both a …

Crosstalk between the phosphatidylinositol 3-kinase (PI3K) and the transforming growth
factor-β signalling pathways play an important role in regulating many cellular functions. …

Objective To determine the relative contribution of the gastrointestinal tract and the liver in
lactate metabolism in patients with acute liver failure (ALF) and the effect of liver …

Background Retransplantation candidates are disadvantaged owing to lack of good-quality
liver grafts. Strategies that can facilitate transplantation of suboptimal grafts into retransplant …

Mesenchymal stromal cells (MSCs) have shown promise as a therapy for immune‐mediated
disorders, including transplant rejection. Our group previously demonstrated the efficacy of …

Background Kerbs von Lungren 6 antigen (KL-6) is expressed on the surface of alveolar type
II cells, and elevated plasma and epithelial lining fluid levels of KL-6 have previously been …

High-risk cornea transplant recipients represent a patient population with significant un-met
medical need for more effective therapies to prevent immunological graft rejection due to …