Autoimmune rheumatic diseases, such as RA and SLE, are caused by genetic, hormonal
and environmental factors. Human Endogenous Retroviruses (HERVs) may be triggers of …

Gender identity disorder (GID), or transsexualism as it is more commonly known, is a highly
complex clinical entity. Although the exact aetiology of GID is unknown, several …

Background Treat-to-target goals for patients with systemic lupus erythematosus (SLE) have
been validated to protect against organ damage and to improve quality of life. We aimed to …

Background The unmet need in systemic lupus erythematosus (SLE) with the current standard
of care is widely recognised, but few studies have quantified this. The recent definition of …

Background Targets of treatment for systemic lupus erythematosus (SLE) include the Lupus
Low Disease Activity State (LLDAS), remission, and complete remission. Whether treatment …

Objective. Human endogenous retrovirus (HERV)-K10 has been implicated in the etiology
and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus …

Objective Disease activity monitoring in SLE includes serial measurement of anti-double
stranded-DNA (dsDNA) antibodies, but in patients who are persistently anti-dsDNA positive, the …

Background The selection and categorisation of laboratory tests in disease activity measures
used within systemic lupus erythematosus (SLE) trial endpoints lack strong evidence. We …

As COVID-19 ravages healthcare systems worldwide, cases of infection among patients
with systemic lupus erythematosus (SLE) are increasingly reported. While there had been 2 …

Objective In trials of systemic lupus erythematosus (SLE), the SLE Responder Index (SRI) is
the most commonly used primary efficacy end point but has limited validation against long‐…