User profiles for Nikita Abraham

Nikita Abraham

Schrodinger
Verified email at schrodinger.com
Cited by 380

[HTML][HTML] Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins

TNT Ho, N Abraham, RJ Lewis - Frontiers in Neuroscience, 2020 - frontiersin.org
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated
ion channels that mediate fast neurotransmission in the central and peripheral …

[HTML][HTML] Neuronal nicotinic acetylcholine receptor modulators from cone snails

N Abraham, RJ Lewis - Marine Drugs, 2018 - mdpi.com
Marine cone snails are a large family of gastropods that have evolved highly potent venoms
for predation and defense. The cone snail venom has exceptional molecular diversity in …

Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport

…, V Bugay, S Wang, N Abraham… - American Journal …, 2016 - journals.physiology.org
The physiological significance of the renal tubular prorenin receptor (PRR) has been
difficult to elucidate due to developmental abnormalities associated with global or renal-specific …

Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion

…, D Stuart, E Mironova, N Abraham… - American Journal …, 2018 - journals.physiology.org
The collecting duct is the predominant nephron site of prorenin and prorenin receptor (PRR)
expression. We previously demonstrated that the collecting duct PRR regulates epithelial …

[HTML][HTML] Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor

N Abraham, M Healy, L Ragnarsson, A Brust… - Scientific reports, 2017 - nature.com
Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human
diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have been …

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors

…, M Mobli, J Lawson, HS Tae, N Abraham… - Journal of the …, 2015 - ACS Publications
Covalently attached peptide dendrimers can enhance binding affinity and functional activity.
Homogenous di- and tetravalent dendrimers incorporating the α7-nicotinic receptor blocker …

[HTML][HTML] Increased frequency of pneumothorax and pneumomediastinum in COVID-19 patients admitted in the ICU: A multicentre study from Mumbai, India

…, A Sunavala, U Agrawal, V Nanda, N Abraham… - Clinical …, 2021 - ncbi.nlm.nih.gov
Background There are limited data regarding the incidence of pneumothorax in COVID-19
patients as well as the impact of the same on patient outcomes. Methods A retrospective …

[HTML][HTML] Insulin use in chronic kidney disease and the risk of hypoglycemic events

D Grube, G Wei, R Boucher, N Abraham, N Zhou… - BMC nephrology, 2022 - Springer
Background We examined in persons with type 2 diabetes (T2D) whether the use of insulin
and the risk of serious hypoglycemic events with insulin is higher in persons with more …

MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors

AH Jin, I Vetter, S Dutertre, N Abraham, NB Emidio… - Biochemistry, 2014 - ACS Publications
α-Conotoxins are competitive antagonists of nicotinic acetylcholine receptors (nAChRs).
Their high selectivity and affinity for the various subtypes of nAChRs have led to significant …

[HTML][HTML] Potency-and selectivity-enhancing mutations of conotoxins for nicotinic acetylcholine receptors can be predicted using accurate free-energy calculations

D Katz, MA DiMattia, D Sindhikara, H Li, N Abraham… - Marine Drugs, 2021 - mdpi.com
Nicotinic acetylcholine receptor (nAChR) subtypes are key drug targets, but it is challenging
to pharmacologically differentiate between them because of their highly similar sequence …