Context: Mutation of the G protein-coupled receptor 54 is associated with a failure of
reproductive function. The endogenous neuropeptide agonist for G protein-coupled receptor 54, …

The role of gastrointestinal hormones in the regulation of appetite is reviewed. The gastrointestinal
tract is the largest endocrine organ in the body. Gut hormones function to optimize the …

Context: Kisspeptin, the endogenous ligand of the G protein-coupled receptor 54, is a key
regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit …

The increasing prevalence of obesity worldwide has imparted renewed impetus to the study
of the mechanisms of appetite regulation. Digestion and nutrient absorption take place in the …

Background: Kisspeptin is a critical regulator of normal reproductive function. A single
injection of kisspeptin in healthy human volunteers potently stimulates gonadotropin release. …

Food intake and energy expenditure are tightly regulated by the brain, in a homeostatic
process that integrates diverse hormonal, neuronal and metabolic signals. The gastrointestinal …

The current obesity epidemic is fuelled by the availability of highly palatable, calorie-dense
food, and the low requirement for physical activity in our modern environment. If energy …

Fasting during the month of Ramadan is a religious rituals of all healthy adult Muslims.
However, there is no clear agreement on the effects of Ramadan fasting on cardiovascular …

We have used manganese-enhanced magnetic resonance imaging (MEMRI) to show distinct
patterns of neuronal activation within the hypothalamus and brainstem of fasted mice in …

Kisspeptin is a 54-amino acid peptide, encoded by the anti-metastasis gene KiSS-1, that
activates G protein-coupled receptor 54 (GPR54). The kisspeptin-GPR54 system is critical to …