Interleukin-1 and neuronal injury
SM Allan, PJ Tyrrell, NJ Rothwell - Nature Reviews Immunology, 2005 - nature.com
Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including
activation of many inflammatory processes (through activation of T cells, for example), …
activation of many inflammatory processes (through activation of T cells, for example), …
Detection of atrial fibrillation after ischemic stroke or transient ischemic attack: a systematic review and meta-analysis
Background and Purpose— Atrial fibrillation (AF) confers a high risk of recurrent stroke,
although detection methods and definitions of paroxysmal AF during screening vary. We …
although detection methods and definitions of paroxysmal AF during screening vary. We …
Inflammation and infection in clinical stroke
HCA Emsley, PJ Tyrrell - Journal of Cerebral Blood Flow & …, 2002 - journals.sagepub.com
Stroke has enormous clinical, social, and economic implications, and demands a significant
effort from both basic and clinical science in the search for successful therapies. …
effort from both basic and clinical science in the search for successful therapies. …
A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients
…, A Vail, SJ Hopkins, NJ Rothwell, PJ Tyrrell - Journal of Neurology …, 2005 - jnnp.bmj.com
Objectives: The cytokine interleukin (IL)-1 mediates ischaemic brain damage in rodents. The
endogenous, highly selective, IL-1 receptor antagonist (IL-1ra) protects against ischaemic …
endogenous, highly selective, IL-1 receptor antagonist (IL-1ra) protects against ischaemic …
Diagnosis of stroke-associated pneumonia: recommendations from the pneumonia in stroke consensus group
Background and Purpose— Lower respiratory tract infections frequently complicate stroke
and adversely affect outcome. There is currently no agreed terminology or gold-standard …
and adversely affect outcome. There is currently no agreed terminology or gold-standard …
An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
…, GJ Del Zoppo, NJ Rothwell, PJ Tyrrell… - Journal of …, 2003 - Elsevier
Central nervous system and peripheral inflammation is important in the responses to ischaemic
stroke, and may also predispose to its development. We aimed to identify (1) the extent …
stroke, and may also predispose to its development. We aimed to identify (1) the extent …
Poststroke shoulder pain: a prospective study of the association and risk factors in 152 patients from a consecutive cohort of 205 patients presenting with stroke
…, E Barberan, HU Laasch, D Bowsher, PJ Tyrrell… - European journal of …, 2002 - Elsevier
BACKGROUND AND PURPOSE Shoulder pain is known to retard rehabilitation after stroke.
Its causes and prognosis are uncertain. This study describes the incidence of poststroke …
Its causes and prognosis are uncertain. This study describes the incidence of poststroke …
Impact of centralising acute stroke services in English metropolitan areas on mortality and length of hospital stay: difference-in-differences analysis
… patient representative5, Anthony G Rudd professor of stroke medicine6, Lee H Schwamm
professor of neurology7, Simon J Turner senior research associate1, Pippa J Tyrrell professor …
professor of neurology7, Simon J Turner senior research associate1, Pippa J Tyrrell professor …
[HTML][HTML] Brain inflammation is induced by co-morbidities and risk factors for stroke
…, SD Proctor, JC Russell, SJ Hopkins, PJ Tyrrell… - Brain, behavior, and …, 2011 - Elsevier
Chronic systemic inflammatory conditions, such as atherosclerosis, diabetes and obesity
are associated with increased risk of stroke, which suggests that systemic inflammation may …
are associated with increased risk of stroke, which suggests that systemic inflammation may …
The association between delays in screening for and assessing dysphagia after acute stroke, and the risk of stroke-associated pneumonia
…, P Enderby, M James, L Paley, PJ Tyrrell… - Journal of Neurology …, 2017 - jnnp.bmj.com
Background There is no robust evidence that screening patients with acute stroke for dysphagia
reduces the risk of stroke-associated pneumonia (SAP), or of how quickly it should be …
reduces the risk of stroke-associated pneumonia (SAP), or of how quickly it should be …