Are preventive drugs preventive enough? A study of patients' expectation of benefit from preventive drugs

PN Trewby, AV Reddy, CS Trewby, VJ Ashton… - Clinical …, 2002 - ncbi.nlm.nih.gov
Objectives-The study aimed to find the threshold of benefit for a hypothetical cholesterol-lowering
drug below which the subject would not be prepared to take the drug. We also looked …

Incidence and pathophysiology of pulmonary edema in fulminant hepatic failure

PN Trewby, R Warren, S Contini, WA Crosbie… - Gastroenterology, 1978 - Elsevier
Thirty-seven of 100 consecutive patients with fulminant hepatic failure had clinical and
radiological evidence of pulmonary edema. None of them had clinical evidence of left heart failure…

A prospective randomised controlled trial of tamoxifen and cyproterone acetate in pancreatic carcinoma

…, BG Gazzard, N Krasner, PM Smith, PN Trewby… - British Journal of …, 1989 - nature.com
In a prospective controlled clinical trial, 108 patients with pancreatic adenocarcinoma were
randomly allocated to receive tamoxifen 20 mg bd, cyproteron acetate 100 mg tds or no …

Pathophysiology of hypotension in patients with fulminant hepatic failure.

PN Trewby, R Williams - Gut, 1977 - gut.bmj.com
Studies on the incidence and pathophysiology of hypotension in fulminant hepatic failure
showed that 82 out of 94 patients developed arterial hypotension with a systolic blood pressure …

Treatment of fulminant hepatic failure by polyacrylonitrile-membrane haemodialysis

DBA Silk, PN Trewby, RA Chase, PJ Mellon, MA Hanid… - The Lancet, 1977 - Elsevier
24 patients with fulminant hepatic failure who had deteriorated to grade-IV coma were treated
by repeated periods of hæmodialysis with a polyacrylonitrile membrane. 9 patients fully …

Intracranial pressure in pigs with surgically induced acute liver failure

…, RE Jenner, RA Chase, PJ Mellon, PN Trewby… - Gastroenterology, 1979 - Elsevier
Cerebral edema has now been noted to occur frequently in patients dying of fulminant hepatic
failure. In the present study, intracranial pressure was monitored in an animal model of …

Assisting international medical graduates applying for their first post in the UK: what should be done?

PN Trewby - Clinical medicine, 2005 - ncbi.nlm.nih.gov
The number of international medical graduates (IMGs) passing the Professional and Linguistic
Assessment Board (PLAB) examination was six times greater in 2004 than in 2000. This …

Liver disease as presenting manifestation of Hodgkin's disease

PN Trewby, B Portmann, DM Brinkley… - QJM: An International …, 1979 - academic.oup.com
Six patients who were referred to the liver unit on account of jaundice are described. A
different initial diagnosis has been made in each case, these being fulminant hepatic failure, …

Plasma amino acid profiles in patients with fulminant hepatic failure treated by repeated polyacrylonitrile membrane hemodialysis

RA Chase, M Davies, PN Trewby, DBA Silk, R Williams - Gastroenterology, 1978 - Elsevier
Raised plasma amino acid concentrations have been implicated in the pathogenesis of
hepatic encephalopathy. In the present study the effect of repeated 4- to 6-hr polyacrylonitrile …

Splenic atrophy in adult coeliac disease: is it reversible?

PN Trewby, PM Chipping, SJ Palmer, PD Roberts… - Gut, 1981 - gut.bmj.com
A study of splenic function in 28 patients with adult coeliac disease showed no significant
correlation between the half life of heat-damaged red cells and either the duration of pre-…