[HTML][HTML] Austerity: a failed experiment on the people of Europe

M McKee, M Karanikolos, P Belcher, D Stuckler - Clinical medicine, 2012 - ncbi.nlm.nih.gov
Many governments in Europe, either of their own volition or at the behest of the international
financial institutions, have adopted stringent austerity policies in response to the financial …

Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds

BAR Williams, CW Diehnelt, P Belcher… - Journal of the …, 2009 - ACS Publications
A full understanding of the proteome will require ligands to all of the proteins encoded by
genomes. While antibodies represent the principle affinity reagents used to bind proteins, their …

The influence of European law on national health policy

…, E Mossialos, P Belcher - Journal of European …, 1996 - journals.sagepub.com
Formally, the European Union has relatively little role in health and health care. This paper
offers a guide to those responsible for devel oping and implementing health policy within the …

[HTML][HTML] Discovery of high-affinity protein binding ligands–backwards

CW Diehnelt, M Shah, N Gupta, PE Belcher… - PLoS …, 2010 - journals.plos.org
Background There is a pressing need for high-affinity protein binding ligands for all proteins
in the human and other proteomes. Numerous groups are working to develop protein …

[HTML][HTML] Medical migration within Europe: opportunities and challenges

K Ling, P Belcher - Clinical medicine, 2014 - ncbi.nlm.nih.gov
The free movement of European citizens to live and work within the European Union (EU) is
one of the fundamental pillars of the European single market. Recent EU legislation on the …

Antineoplastic agents. 599. Total synthesis of dolastatin 16

…, JC Chapuis, JP Xu, TL Groy, PE Belcher… - Journal of natural …, 2015 - ACS Publications
The first 23-step total synthesis of the cyclodepsipeptide dolastatin 16 (1) has been achieved.
Synthesis of the dolaphenvaline and dolamethylleuine amino acid units using simplified …

2-Aryl-5, 5-bisoxazolin-2-yl [1, 3] dioxanes as solution phase and immobilised ligands for highly enantioselective cyclopropanations

JG Knight, PE Belcher - Tetrahedron: Asymmetry, 2005 - Elsevier
2-Aryl-5,5-bisoxazolin-2-yl[1,3]dioxanes 5, which can be easily prepared in three steps from
diethyl bishydroxymethylmalonate, amino alcohol and an aromatic aldehyde, have been …

Engineering a synthetic ligand for tumor necrosis factor–alpha

N Gupta, PE Belcher, SA Johnston… - Bioconjugate …, 2011 - ACS Publications
One approach to prepare protein binding ligands is to join two low-affinity ligands that bind
different sites on the target protein to create a high-affinity bivalent ligand. This typically …

Cross-reactive synbody affinity ligands for capturing diverse noroviruses

N Gupta, JC Lainson, PE Belcher, L Shen… - Analytical …, 2017 - ACS Publications
Noroviruses are the most common cause of acute gastroenteritis in the developed world.
Noroviruses are a diverse group of nonenveloped RNA viruses that are continuously evolving. …

[HTML][HTML] Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information

MP Greving, PE Belcher, CW Diehnelt… - PLoS …, 2010 - journals.plos.org
Background There is a significant need for affinity reagents with high target affinity/specificity
that can be developed rapidly and inexpensively. Existing affinity reagent development …