Background— Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a
receptor member of the transforming growth factor-β (TGF-β) superfamily, underlie many …

Background Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a
receptor member of the transforming growth factor-β (TGF-β) superfamily, underlie many cases …

Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II)
signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH…

We determined the distribution of ET A and ET B receptors in pulmonary arteries from
pulmonary hypertensive patients and control subjects, using in vitro autoradiography, and …

Mutations in the bone morphogenetic protein type II receptor gene (BMPR2) are the major
genetic cause of familial pulmonary arterial hypertension (FPAH). Although smooth muscle …

Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious
variation within components of the transforming growth factor-β pathway, particularly the …

Hereditary hemorrhagic telangiectasia (HHT), the most common inherited vascular disorder,
is caused by mutations in genes involved in the transforming growth factor beta (TGF-β) …

Rationale: Despite improved understanding of the underlying genetics, pulmonary arterial
hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary …

Background— Recent genetic studies have highlighted the role of the bone morphogenetic
protein (BMP)/transforming growth factor (TGF)-β signaling pathways in the pathogenesis of …

Adrenomedullin has been proposed to be a circulating hormone regulating systemic and
pulmonary blood pressure. A potential therapeutic role in the management of pulmonary …