Prostate cancer represents a substantial clinical challenge because it is difficult to predict
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …

The aim of this study was to ascertain the level of concordance among gastrointestinal
pathologists for regression grading in rectal cancers treated with neoadjuvant chemoradiation. …

A variety of models have been proposed to explain regions of recurrent somatic copy number
alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (…

Aim An audit of serrated polyps diagnosed over a 4-year period: 2009 to 2012 was undertaken
to ascertain the reporting trends of sessile serrated polyps (SSP). Methods All right sided …

Genetic signatures have added a molecular dimension to prognostics and therapeutic
decision-making. However, tumour heterogeneity in prostate cancer and current sampling …

The role of focal brain damage as a trigger for autoimmune inflammation in multiple sclerosis
(MS) is unclear. In this study we examine mechanisms by which experimental autoimmune …

To ascertain the approach and degree of consensus of pathologists in the handling and
regression grading of colorectal cancer resection specimens treated with neoadjuvant …

Aim The purpose of this survey was to ascertain reporting habits of pathologists towards
sessile serrated adenomas/polyps (SSA/P). Methods A questionnaire designed to highlight …

This article reviews previously described methods of fresh tissue sampling from radical
prostatectomy specimens for research and describes a method used in Oxford which is simple, …

There is a 10% shortfall in the number of proximal colorectal cancer cases detected by the
UK Bowel Cancer Screening Programme and the actual number of UK-registered proximal …