Epstein–Barr virus (EBV) is a herpesvirus associated with approximately 1% of tumours
worldwide. EBV is the epitome of B lymphotropic viruses, but the spectrum of tumours it is …

In the past two decades, the treatment of metastatic non-small cell lung cancer (NSCLC),
has undergone significant changes due to the introduction of targeted therapies and …

Purpose To evaluate the role of germline SDHA mutation analysis by (1) comprehensive
literature review, (2) description of novel germline SDHA mutations and (3) in silico structural …

Context: Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur
in the same patient or in the same family. Coexistence of the two diseases could be due to …

Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

TP53 mutations are common in lung cancers of smokers, with high prevalence of G:C-to-T:A
transversions generally interpreted as mutagen fingerprints of tobacco smoke. In this study, …

Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4, and BRDT) are transcriptional
regulators required for efficient expression of several growth promoting and antiapoptotic …

Novelli M, Rossi S, Rodriguez‐Justo M, Taniere P, Seddon B, Toffolatti L, Sartor C, Hogendoorn
PCW, Sciot R, Van Glabbeke M, Verweij J, Blay JY, Hohenberger P, Flanagan A & Dei …

Fas (APO-1/CD95) is a cell surface receptor that mediates apoptosis when it reacts with Fas
ligand (FasL) or Fas antibody. In this study, we analyzed Fas and FasL expression in normal …

Introduction The identification of tumour mutational burden (TMB) as a biomarker of
response to programmed cell death protein 1 (PD-1) immunotherapy has necessitated the …