… Further, the practical rationale for this paper is to build on the work of Selvaratnam and
Sankey (2019). Their findings for the Australasian Council for Open, Distance and eLearning (…

… Author links open overlay panel Anglin Dent a , Rajeevan Selvaratnam a b … U r i n a r y M
a g n e s i u m × [ P l a s m a C r e a t i n i n e ] 0.7 × P l a s m a M a g n e s i u m × U r i n a r y C r …

… highest absolute value of the correlation coefficient within R. A second intracluster link is then
… 3B shows the dendrogram for the largest cluster found in R with a cutoff of |r ij |≥0.98 (SI …

… H populations of apo R A , we compared the HN correlation spectra of apo R A to those
of the same construct bound to either C or cAMP, which approximate the H and B states, …

EPAC is a cAMP-dependent guanine nucleotide exchange factor that serves as a prototypical
molecular switch for the regulation of essential cellular processes. Although EPAC …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels control neuronal
and cardiac electrical rhythmicity. There are four homologous isoforms (HCN1–4) sharing a …

Hypoglossal (XII) motoneurons (MNs) contribute to diverse behaviors. Their innervation of
the genioglossus muscle, a tongue protruder, plays a critical role in maintaining upper airway …

The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins
activated by cAMP (EPAC). The CBD maintains EPAC in a state of auto-inhibition in the …

… Specifically, in the PKA system cGMP is an agonist of cAMP, ie cGMP is able to activate
PKA once it binds the R subunit. However, the affinity of cGMP for the PKA R subunit is …

… In this case, the comparative structural analysis of R bound to either the kinase subunit (C)
or to cAMP is effective in revealing the cAMP-dependent allosteric networks within the …