We review the principles and practical application of receiver-operating characteristic (ROC)
analysis for diagnostic tests. ROC analysis can be used for diagnostic tests with outcomes …

Young people make up the segment of society that has the greatest potential to benefit from
policies and health initiatives based on sound research and information. The Health …

The implementation of targeted therapies for acute myeloid leukaemia (AML) has been
challenging because of the complex mutational patterns within and across patients as well as a …

This paper presents the output of our fifth annual horizon-scanning exercise, which aims to
identify topics that increasingly may affect conservation of biological diversity, but have yet to …

Dual-photon absorptiometry (DPA) allows separation of body mass into bone mineral, fat,
and fat-free soft tissue. This report evaluates the potential of DPA to isolate appendages of …

The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including
transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the …

Background Weight lifting has generally been proscribed for women with breast-cancer–related
lymphedema, preventing them from obtaining the well-established health benefits of …

Background Tuberculous sputum provides a sample of bacilli that must be eliminated by
chemotherapy and that may go on to transmit infection. A preliminary observation that …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by
progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of …

Context Clinical guidelines for breast cancer survivors without lymphedema advise against
upper body exercise, preventing them from obtaining established health benefits of weight …