User profiles for Robert Grange

Robert Grange

Professor, Human Nutrition, Foods, and Exercise, Virginia Tech
Verified email at vt.edu
Cited by 6969

The Galaxy Evolution Explorer: a space ultraviolet survey mission

…, TA Barlow, T Conrow, R Grange… - The Astrophysical …, 2005 - iopscience.iop.org
We give an overview of the Galaxy Evolution Explorer (GALEX), a NASA Explorer Mission
launched on 2003 April 28. GALEX is performing the first space UV sky survey, including …

The on-orbit performance of the Galaxy Evolution Explorer

…, J Fanson, PG Friedman, R Grange… - The Astrophysical …, 2005 - iopscience.iop.org
We report the first year's on-orbit performance results for the Galaxy Evolution Explorer (GALEX),
a NASA Small Explorer that is performing a survey of the sky in two ultraviolet bands. …

Role for α-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies

RM Grady, RW Grange, KS Lau, MM Maimone… - Nature cell …, 1999 - nature.com
A dystrophin-containing glycoprotein complex (DGC) links the basal lamina surrounding each
muscle fibre to the fibre’s cytoskeleton, providing both structural support and a scaffold for …

Mice without myoglobin

…, JN Lorenz, NB Radford, ER Chin, RW Grange… - Nature, 1998 - nature.com
Myoglobin, an intracellular haemoprotein expressed in the heart and oxidative skeletal
myofibres of vertebrates, binds molecular oxygen and may facilitate oxygen transport from …

[HTML][HTML] Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury

M Liu, Y Yue, SQ Harper, RW Grange… - Molecular Therapy, 2005 - cell.com
Duchenne muscular dystrophy (DMD) is the most common inherited lethal muscle degenerative
disease. Currently there is no cure. Highly abbreviated microdystrophin cDNAs were …

Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies

…, P Nghiem, DA Detwiler, CA Larsen, RW Grange… - Mammalian …, 2012 - Springer
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder in which the loss of
dystrophin causes progressive degeneration of skeletal and cardiac muscle. Potential …

Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy

…, R Joubert, K Poulard, C Moal, RW Grange… - Science translational …, 2014 - science.org
Loss-of-function mutations in the myotubularin gene (MTM1) cause X-linked myotubular
myopathy (XLMTM), a fatal, congenital pediatric disease that affects the entire skeletal …

[HTML][HTML] Sulfide catabolism ameliorates hypoxic brain injury

…, M Morita, S Hirai, S Kai, RMH Grange… - Nature …, 2021 - nature.com
The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism
underlying the brain’s sensitivity to hypoxia is incompletely understood. Hypoxia induces …

[HTML][HTML] Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy

…, Y Wu, KA Voelker, RW Grange… - The Journal of …, 2011 - Am Soc Clin Investig
MicroRNAs modulate cellular phenotypes by inhibiting expression of mRNA targets. In this
study, we have shown that the muscle-specific microRNAs miR-133a-1 and miR-133a-2 are …

Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6

…, J Pei, NV Grishin, RW Grange… - Proceedings of the …, 2011 - National Acad Sciences
In response to physiological stimuli, skeletal muscle alters its myofiber composition to
significantly affect muscle performance and metabolism. This process requires concerted …