Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
RW Chapman, BA Arborgh, JM Rhodes… - Gut, 1980 - gut.bmj.com
Twenty-nine patients with primary sclerosing cholangitis were reviewed. Males predominated
(2:1). Seventy-six per cent presented with cholestasis and cholangitis, 17% with cirrhosis …
(2:1). Seventy-six per cent presented with cholestasis and cholangitis, 17% with cirrhosis …
[HTML][HTML] Overlap syndromes: the International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue
KM Boberg, RW Chapman, GM Hirschfield… - Journal of …, 2011 - Elsevier
Some patients presenting with overlapping features between disorders within the spectrum
of autoimmune liver diseases (ie autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), …
of autoimmune liver diseases (ie autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), …
Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis
…, A Cheung, M Trauner, C Schramm, RW Chapman… - Gastroenterology, 2017 - Elsevier
Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary
disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of …
disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of …
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …
A preliminary trial of high-dose ursodeoxycholic acid in primary sclerosing cholangitis
…, N Hunt, K Von Bergmann, KA Fleming, RW Chapman - Gastroenterology, 2001 - Elsevier
Background & Aims: Ursodeoxycholic acid (UDCA) is used for the treatment of cholestatic
liver diseases including primary biliary cirrhosis (PBC) for which it has a positive effect on …
liver diseases including primary biliary cirrhosis (PBC) for which it has a positive effect on …
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
…, G Alexander, DJ Gaffney, RW Chapman… - Nature …, 2017 - nature.com
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook …
destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook …
The natural history of small-duct primary sclerosing cholangitis
…, A Bergquist, S Lindgren, B Braden, RW Chapman… - Gastroenterology, 2008 - Elsevier
Background & Aims: The long-term prognosis of patients with small-duct primary sclerosing
cholangitis (PSC) remains incompletely characterized. We aimed at determining the natural …
cholangitis (PSC) remains incompletely characterized. We aimed at determining the natural …
Primary sclerosing cholangitis: refinement and validation of survival models
…, J Ludwig, NF LaRusso, M Malinchoc, RW Chapman… - Gastroenterology, 1992 - Elsevier
The natural history of primary sclerosing cholangitis was studied in 426 patients from five
medical centers. The median follow-up time was 3.0 years (range, 0.01–16.6 years); 100 …
medical centers. The median follow-up time was 3.0 years (range, 0.01–16.6 years); 100 …
Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis
…, A Miller, PJ McHugh, RW Chapman… - Human molecular …, 2003 - academic.oup.com
Haemochromatosis (HH) is a clinically and genetically heterogeneous disease caused by
inappropriate iron absorption. Most HH patients are homozygous for the C282Y mutation in …
inappropriate iron absorption. Most HH patients are homozygous for the C282Y mutation in …
Improvement of serum alkaline phosphatase to< 1.5 upper limit of normal predicts better outcome and reduced risk of cholangiocarcinoma in primary sclerosing …
…, J Djordjevic, JS Halliday, RW Chapman - Journal of hepatology, 2013 - Elsevier
BACKGROUND & AIMS: Normalization of serum alkaline phosphatase (SAP) was recently
shown to correlate with better prognosis in Primary Sclerosing Cholangitis (PSC). We aimed …
shown to correlate with better prognosis in Primary Sclerosing Cholangitis (PSC). We aimed …