A genetic component to the cause of inflammatory bowel disease has been inferred from
the increased risk among first degree relatives (5-20% cumulative incidence). 1 The only …

Background & Aims: α4 integrins are important mediators of leukocyte migration across vascular
endothelium. This pilot placebo-controlled study aimed to assess the safety and efficacy …

Intestinal permeability to a monosaccharide and a disaccharide was compared by simultaneous
measurement of the urinary excretion of L-rhamnose and lactulose after oral ingestion …

The Inflammatory Bowel Disease Study Group at the Royal Free Hospital School of Medicine
has tested the hypothesis that the primary pathological abnormality in Crohn's disease is in …

Background/Aims: Crohn's disease and ulcerative colitis seem to be rarely associated with
inherited diseases of coagulation. Histological and hematologic studies suggest that …

Following the implementation of the European Working Time Directive Regulations, almost
all junior doctors in the UK now work full night-shifts. An RCP 50-member working group was …

Half of the world’s population is infected with Helicobacter pylori, making it a pathogen of
potentially great significance. Although in the majority of cases, infection is harmless, many …

Background & Aims: Measles virus has been implicated in the etiology of both inflammatory
bowel diseases (IBDs), Crohn's disease and ulcerative colitis. Subacute sclerosing …

Design: The 1946 National Survey of Health & Development (NSHD) and the 1958 National
Child Development Study (NCDS) are on-going, longitudinal birth cohort studies. A nested …

Background/Aims: Gastrin is a trophic factor within the normal gastrointestinal tract and is
also a mitogen for a number of gastrointestinal and non-gastrointestinal tumours. Precursor …