With improving lifespan, primary degenerative and vascular dementias are increasingly
being recognised as prominent health problems. The four commonest causes of primary …

Importance Current treatments manage symptoms of Parkinson disease (PD), but no known
treatment slows disease progression. Preclinical and epidemiological studies support the …

An 85-year-old man presented to hospital as an emergency having difficulties with swallowing
and speech. In the emergency department, he was assessed as having acute onset …

We describe a 64-year-old woman with relapsing encephalopathy. She initially presented
with 5 days of psychomotor agitation, progressing to mania, psychosis and seizures that …

We describe an unusual presentation of myeloperoxidase positive antineutrophil cytoplasmic
antibody (ANCA)-associated vasculitis managed by a multidisciplinary approach. A 75-year…

A 64-year-old lady presented with a one-week history of subtle behavioural change and
increased emo- tionality. She then suffered multiple focal seizures followed by a prolonged …

<p>Natalizumab is highly effective disease modifying agent for relapsing remitting multiple
sclerosis. However, it’s associated with increased risk of progressive multifocal …

BACKGROUND Jaundice is an important problem in the neonatal period. Nearly 60% of
term babies &80% of preterm babies become visibly jaundiced in the first week of life. It is …

… 205 AN UNUSUAL CAUSE OF RAPID COGNITIVE DECLINE IN MULTIPLE SCLEROSIS
PATIENT ON NATALIZUMAB Amar Elsaddig, Saifuddin Shaik. Royal Preston Hospital 10.1136/…

Skin lesion segmentation is the essential step in automated computer-aided diagnosis of
malignant melanoma. However, this task might be challenging when there are variations in …