Background High blood pressure is common in acute stroke and is a predictor of poor
outcome; however, large trials of lowering blood pressure have given variable results, and the …

Background and Purpose— The practicalities of doing ambulance-based trials where
paramedics perform all aspects of a clinical trial involving patients with ultra-acute stroke have not …

Objective We set out to determine which characteristics and outcomes of stroke are associated
with COVID-19. Methods This case-control study included patients admitted with stroke to …

Background Stroke is associated with the development of cognitive impairment and dementia.
We assessed the effect of intensive blood pressure (BP) and/or lipid lowering on cognitive …

Post stroke dementia (PSD) develops in up to 40% of patients and often co-exists with
Alzheimer's disease in the elderly. Unsurprisingly, the combination of stroke and dementia is …

Background Poststroke cognitive impairment is common and identification of prognostic
factors associated with it and its relationship with other functional outcomes may help in …

The main driving force behind the assessment of novel pharmacological agents in animal
models of stroke is to deliver new drugs to treat the human disease rather than to increase …

Background The effect of transdermal glyceryl trinitrate (GTN, a nitrovasodilator) on clinical
outcome when administered before hospital admission in suspected stroke patients is unclear…

Study objective Optimal practices for recruiting, consenting, and randomizing patients, and
delivering treatment in out-of-hospital ultra-acute stroke trials, remain unclear. We aim to …

Background Prehospital stroke trials will inevitably recruit patients with non-stroke conditions,
so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in …