Inherited retinal disease is a common cause of visual impairment and represents a highly
heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals …

Neutrophils play essential anti-microbial and inflammatory roles in host defense, however,
their activities require tight regulation as dysfunction often leads to detrimental inflammatory …

Background Myeloperoxidase released after neutrophil and monocyte activation can
generate reactive oxygen species, leading to host tissue damage. Extracellular glomerular …

Goodpasture’s or anti-glomerular basement membrane (GBM) disease is classically
characterized by the presence of circulating autoantibodies directed against the non-collagenous …

IN May 1988, the World Health Assembly declared that the World Health Organization was
committed to the global eradication of poliomyelitis by the year 2000. The eradication of …

Objectives To investigate key factors that may contribute to the variability of rituximab-mediated
peripheral and renal B cell depletion (BCD) in SLE. Methods We analysed: (i) CD19+ B …

Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are
autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target …

Objectives Cocaine and cocaine mixed with levamisole are increasingly used in the UK and
result in significant direct nasal damage in addition to promoting vasculitis. Our aims were …

About 40 trans-Neptunian binaries (TNBs) have fully determined orbits with about 10 others
being solved except for breaking the mirror ambiguity. Despite decades of study, almost all …

Pulmonary nodule formation is a frequent feature of granulomatosis with polyangiitis (GPA).
Traditional induction therapy includes methotrexate or cyclophosphamide, however, …