We reviewed the notes of 197 patients with Duchenne muscular dystrophy whose treatment
was managed at the Newcastle muscle centre from 1967 to 2002, to determine whether …

The Faculty of Intensive Care Medicine and Intensive Care Society Guideline Development
Group have used GRADE methodology to make the following recommendations for the …

The vascular endothelium has a central role in the control of microvascular tone, and it has
been proposed that vascular endothelial damage occurs in septic shock, producing …

Objective Epidemiological studies demonstrate that inherited factors play a major role in the
development and prognosis of sepsis. However, genetic association studies in sepsis have …

Background Early physical rehabilitation in the intensive care unit (ICU) has been shown to
improve short-term clinical outcomes but long-term benefit has not been proven and the …

Background Human genome evolution has been shaped by infectious disease. Although
most genetic studies have focused on the immune system, recovery after sepsis is directly …

Objective To examine the hypothesis that neutrophil chemotaxis to interleukin-8 (IL-8) is
reduced in septic shock. Surface expression of neutrophil CXC chemokine receptors and the …

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing
millions of global deaths each year. To alleviate this burden, improved prognostication and …

Background Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired
infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. …

Background Excessive use of empirical antibiotics is common in critically ill patients. Rapid
biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-…