ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL)
functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because …

Loss-of-function mutations of PRC2 genes are associated with chemotherapy resistance in T-ALL,
yet no specific therapy for this aggressive subtype is currently clinically available. Our …

T‐cell ALL (T‐ALL) is an aggressive malignancy of T‐cell progenitors. Although survival
outcomes in T‐ALL have greatly improved over the past 50 years, relapsed and refractory cases …

Head injury is a common cause for hospital admission and additionally 250,000 UK inpatients
fall during hospital admissions annually. Head injury most commonly occurs as a result of …

Accurate staging of classical Hodgkin lymphoma (CHL) directs treatment intensity. Functional
imaging can detect marrow/bone involvement making the role of bone marrow biopsy (BMB…

Following reduced intensity‐conditioned allogeneic stem cell transplantation ( RIC allo‐
SCT ) for chronic lymphocytic leukaemia ( CLL ), there is an inverse relationship between …

B cell precursor acute lymphoblastic leukemia (BCP-ALL) is a malignant disorder of immature
B lineage immune progenitors and is the commonest cancer in children. Despite treatment …

Several studies have documented aberrant RNA editing patterns across multiple tumors
across large patient cohorts from The Cancer Genome Atlas (TCGA). However, studies on …

… Author links open overlay panel Simon E. Richardson 1 2 6 , Roshanak Ghazanfari 4 , Jyoti
… be directed to and will be fulfilled by the lead contact, Simon Richardson ([email protected] ). …

Normal hematopoiesis is sustained by multipotent hematopoietic stem cells (HSCs) that are
able to both self-renew and give rise to differentiated cells throughout the lifetime of an …