Context.—There is little information on the extent of persistent pain across cultures. Even
though pain is a common reason for seeking health care, information on the frequency and …

IN Western Europe and the United States approximately 1 in 12 women develop breast cancer.
A small proportion of breast cancer cases, in particular those arising at a young age, are …

Background Patients with depression, particularly those seen by primary care physicians, may
report somatic symptoms, such as headache, constipation, weakness, or back pain. Some …

Background Epidemiologic data suggest an association between obesity and depression,
but findings vary across studies and suggest a stronger relationship in women than men. …

Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …

Objective: Research on the workplace costs of mood disorders has focused largely on major
depressive episodes. Bipolar disorder has been overlooked both because of the failure to …

The human X chromosome has a unique biology that was shaped by its evolution as the sex
chromosome shared by males and females. We have determined 99.3% of the euchromatic …

OBJECTIVE: The purpose of this review is to assess the relationship between mood disorders
and development, course, and associated morbidity and mortality of selected medical …

Objective: The prevalence, burden, and management of insomnia among primary care
patients were evaluated. Method: Consecutive patients aged 18 to 65 years in primary care …

This report describes the World Health Organization Health and Work Performance
Questionnaire (HPQ), a self-report instrument designed to estimate the workplace costs of health …