PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and
oncological diseases through clinical genetics and gene disruption in mice. New selective …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although
genome-wide association studies have identified PAU risk genes, the genetic architecture …

The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins
enable chromatin binding to facilitate transcription. Drugs that inhibit both bromodomains …

Digital clubbing is associated with many unrelated serious diseases but its pathogenesis
remains a clinical enigma. It has been hypothesized that platelet clusters impacting in the distal …

Background & Aims Severe alcoholic hepatitis (AH) has high mortality. We assessed the
comparative effectiveness of pharmacological interventions for severe AH, through a network …

Background & Aims Infections are common in patients with severe alcoholic hepatitis (SAH),
but little information is available on how to predict their development or their effects on …

Background & Aims We performed a meta-analysis of individual patient data from 11
randomized controlled trials comparing corticosteroids, pentoxifylline, or their combination in …

Regional declines in polar bear (Ursus maritimus) populations have been attributed to
changing sea ice conditions, but with limited information on the causative mechanisms. By …

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular
dysfunction for which targeted treatments are urgently needed. Identification of molecular …

While investigating the parasite fauna of wild coho salmon. Oncorhynchus kisutch (Walbaum,
1792), histological examination provided evidence of a new species of Myxobolus (…