The rapid implementation of SARS-CoV-2 vaccination is now a global health-care priority.
Successful phase 3 trial outcomes have been reported for numerous vaccines that induce …

Objective There is an urgent need to assess the impact of immunosuppressive therapies on
the immunogenicity and efficacy of SARS-CoV-2 vaccination. Methods Serological and T-…

Large-vessel vasculitis (LVV) manifests as inflammation of the aorta and its major branches
and is the most common primary vasculitis in adults. LVV comprises two distinct conditions, …

Anti–glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis
that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease…

Background Strategies to minimize the risk of transmission and acquisition of COVID-19
infection in patients with ESKD receiving in-center hemodialysis have been rapidly implemented …

Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare.
Current studies of such ‘double-positive’ cases report small numbers and variable outcomes. …

Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of
branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule …

Background Current guidelines advise that rituximab or cyclophosphamide should be used
for the treatment of organ-threatening disease in anti-neutrophil cytoplasm antibody (ANCA)-…

Data are shown as median with IQR. Statistical analysis is by MannWhitney test (A) or
KruskallWallis test with Dunns posthoc correction (B).(A) Kidney transplant recipients who …

This document follows up on a 2017 revised international consensus on anti-neutrophil
cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic …