Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

Purpose Recent advances in DNA sequencing have led to the development of breast
cancer susceptibility gene panels for germline genetic testing of patients. We assessed the …

Importance Germline pathogenic variants inBRCA1andBRCA2predispose to an increased
lifetime risk of breast cancer. However, the relevance of germline variants in other genes from …

Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …

Importance Individuals genetically predisposed to pancreatic cancer may benefit from early
detection. Genes that predispose to pancreatic cancer and the risks of pancreatic cancer …

Common variants in 94 loci have been associated with breast cancer including 15 loci with
genome-wide significant associations (P<5 × 10 −8 ) with oestrogen receptor (ER)-negative …

HepaRG cells, derived from a female hepatocarcinoma patient, are capable of differentiating
into biliary epithelial cells and hepatocytes. More importantly, differentiated HepaRG cells …

Patients with cholangiocarcinoma often present with locally advanced or metastatic disease.
There is a need for effective therapeutic strategies for advanced stage cholangiocarcinoma. …

Background Germline genetic testing with hereditary cancer gene panels can identify women
at increased risk of breast cancer. However, those at increased risk of triple-negative (…