Guidelines for the management of inflammatory bowel disease in adults
…, L Younge, C Lees, G Ho, J Satsangi, S Bloom… - Gut, 2011 - gut.bmj.com
The management of inflammatory bowel disease represents a key component of clinical
practice for members of the British Society of Gastroenterology (BSG). There has been …
practice for members of the British Society of Gastroenterology (BSG). There has been …
Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue.
…, A Shyjan, N Cochran, S Bloom… - The American journal …, 1997 - ncbi.nlm.nih.gov
Lymphocyte homing to normal tissues and recruitment to inflammatory tissue sites are
controlled, in part, by the selective expression of chemokines, pro-inflammatory cytokines and …
controlled, in part, by the selective expression of chemokines, pro-inflammatory cytokines and …
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
…, R Miller, PS Babu, C Tzivinikos, SL Bloom… - The lancet …, 2019 - thelancet.com
Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
…, T Sweeting, M Marsh, AP Walker, SL Bloom… - Journal of Experimental …, 2009 - rupress.org
The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these
patients possess an impaired acute inflammatory response, which could result in delayed …
patients possess an impaired acute inflammatory response, which could result in delayed …
Defective acute inflammation in Crohn's disease: a clinical investigation
…, J Young, B Al-Lazikani, W Lees, M Novelli, S Bloom… - The Lancet, 2006 - thelancet.com
Background The cause of Crohn's disease has not been mechanistically proven. We tested
the hypothesis that the disease is a form of immunodeficiency caused by impaired innate …
the hypothesis that the disease is a form of immunodeficiency caused by impaired innate …
Non-perforating small bowel Crohn's disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index
…, I Proctor, Y Adjei-Gyamfi, F Chatterjee, S Bloom… - European journal of …, 2012 - Elsevier
OBJECTIVES: To develop and validate a qualitative scoring system for enteric Crohn's disease
activity using MR enterography (MRE). METHODS: MRE was performed in 16 patients (…
activity using MR enterography (MRE). METHODS: MRE was performed in 16 patients (…
Mural inflammation in Crohn disease: location-matched histologic validation of MR imaging features
…, A Bainbridge, R Greenhalgh, E De Vita, S Bloom… - Radiology, 2009 - pubs.rsna.org
Purpose To validate proposed magnetic resonance (MR) imaging features of Crohn disease
activity against a histopathologic reference. Materials and Methods Ethical permission was …
activity against a histopathologic reference. Materials and Methods Ethical permission was …
[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease
…, A Willmott, R Miller, PS Babu, C Tzivinikos, SL Bloom… - Gastroenterology, 2020 - Elsevier
Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally.
Early insights have been made possible by rapid sharing of data from China and Italy. In …
Early insights have been made possible by rapid sharing of data from China and Italy. In …
Use of a biothesiometer to measure individual vibration thresholds and their variation in 519 non-diabetic subjects.
S Bloom, S Till, P Sönksen, S Smith - Br Med J (Clin Res Ed), 1984 - bmj.com
A series of 519 non-diabetic subjects had vibration thresholds at three points measured using
a biothesiometer. Thresholds appeared to be log normally distributed and increased with …
a biothesiometer. Thresholds appeared to be log normally distributed and increased with …