[HTML][HTML] Lupus anticoagulant and abnormal coagulation tests in patients with Covid-19

…, L Green, S Sivapalaratnam… - … England Journal of …, 2020 - Mass Medical Soc
Prolonged aPTT in Patients with Covid-19 In this study, 20% of patients with Covid-19 had a
prolonged activated partial-thromboplastin time. In 90% of these cases, the cause was lupus …

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

…, S Pietri, F Gori, R Marchioli, S Sivapalaratnam… - Nature …, 2011 - nature.com
Genome-wide association studies have identified 11 common variants convincingly associated
with coronary artery disease (CAD) 1 , 2 , 3 , 4 , 5 , 6 , 7 , a modest number considering …

Diagnosis of inherited bleeding disorders in the genomic era

S Sivapalaratnam, J Collins… - British journal of …, 2017 - Wiley Online Library
Inherited bleeding disorders affect between 1 in 1000 individuals for the most common
disorder, von Willebrand Disease, to only 8 reported cases worldwide of alpha‐2‐antiplasmin …

Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome

…, M Kostadima, RJ Read, B Sipos, S Sivapalaratnam… - Nature …, 2011 - nature.com
Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is
characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; these …

Disseminated intravascular coagulation: an update on pathogenesis and diagnosis

M Levi, S Sivapalaratnam - Expert review of hematology, 2018 - Taylor & Francis
Introduction: Activation of the hemostatic system can occur in many clinical conditions.
However, a systemic and strong activation of coagulation complicating clinical settings such as …

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

…, DS Siscovick, M Sivananthan, S Sivapalaratnam… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

[PDF][PDF] The allelic landscape of human blood cell trait variation and links to common complex disease

…, MA Kostadima, JJ Lambourne, S Sivapalaratnam… - Cell, 2016 - cell.com
Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

…, D Saleheen, J Danesh, SE Epstein, S Sivapalaratnam… - Nature, 2015 - nature.com
Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance 1 , 2 . When MI occurs early in life, genetic inheritance is a major …

Mendelian randomization of blood lipids for coronary heart disease

…, EPA Van Iperen, S Sivapalaratnam… - European heart …, 2015 - academic.oup.com
Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian …

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

…, AE Locke, A Mahajan, E Marouli, S Sivapalaratnam… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI),
implicating pathways related to neuronal biology. Most GWAS loci represent clusters of …