BackgroundSchizophrenia affects 1% of the population. Clozapine is the only medication
licensed for treatment-resistant schizophrenia and is intensively monitored to prevent harm …

… In contrast to IKAROS defects but similar to cytotoxic T lymphocyte–associated protein 4 (CTLA4)
haploinsufficiency, we observed that NFKB1 haploinsufficiency can also result in …

Background A wealth of evidence obtained using mouse models indicates that CD4 + CD25
+ FOXP3 + regulatory T cells (Treg) maintain peripheral tolerance to self-antigens and also …

Background There is indirect evidence that T cell responses can control the metastatic spread
of colorectal cancer (CRC). However, an enrichment of CD4 + Foxp3 + regulatory T cells (…

This report summarizes the establishment of the first national online registry of primary
immune deficency in the United Kingdom, the United Kingdom Primary Immunodeficiency (UKPID …

… The observed difference can be explained by our definition of CVID, 16 which did not
exclude patients with a T-cell defect. However, a measurable CD4 T-cell defect was observed in …

A diagnosis of idiopathic anaphylaxis following a detailed clinical assessment remains very
challenging for patients and clinicians. Risk reduction strategies such as allergen avoidance …

Hereditary angioedema (HAE) and acquired angioedema (AAE) are rare life-threatening
conditions caused by deficiency of C1 inhibitor (C1INH). Both are characterized by recurrent …

Calculated globulin (total protein – albumin) is usually tested as part of a liver function test
profile in both primary and secondary care and determines the serum globulin concentration, …

Background: Allergy is diagnosed from typical symptoms, and tests are performed to incriminate
the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, …