Aims: To determine time trends in hospital admissions for chronic liver disease in England
between 1989/1990 and 2002/2003, mortality rates in England and Wales between 1979 and …

Objective To compare urine output between junior doctors in an intensive care unit and the
patients for whom they are responsible. Design Case-control study. Setting General intensive …

Previous studies have demonstrated that alginate encapsulation of proliferating hepatocyte‐derived
cell lines (eg, HepG2 cells) enhances the expression of differentiated hepatocyte …

… We are indebted to the assistance of the dedicated research staff in the ICU at St Thomas’
Hospital led by Tony Sherry and for the generous efforts of Angela Jurukov on the ICU at St …

Introduction The number of patients admitted to ICU who have liver cirrhosis is rising. Current
prognostic scoring tools to predict ICU mortality have performed poorly in this group. In …

Background: The circulatory dysfunction associated with cirrhosis is well described.
Reduced systemic vascular resistance and high cardiac output are the main features of the …

Chronic liver diseases (CLDs) can cause progressive hepatic fibrosis culminating in cirrhosis.
Fibrosis staging requires liver biopsy, which is invasive, expensive and frequently poorly …

and extravascular fluid volumes adequate (as assessed from skin turgor and subcutaneous
tissues)? 3 Is the patient fluid overloaded/in danger of pulmonary oedema? An arterial (or …

Gastrointestinal bleeding (GIB) in the critical care environment is a relatively common clinical
event. The incidence of GIB is 103/100,000 cases per year in the United Kingdom (UK). Of …

In conclusion, ADMA, SDMA and their combined interaction, are promising biomarkers in
the assessment and staging of disease severity in the field of chronic and acute-on-chronic …