Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis

U Clancy, D Gilmartin, ACC Jochems, L Knox… - The Lancet …, 2021 - thelancet.com
Background Cerebral small vessel disease, a common cause of vascular dementia, is often
considered clinically silent before dementia or stroke become apparent. However, some …

Clinical management of cerebral small vessel disease: a call for a holistic approach

U Clancy, JP Appleton, C Arteaga, FN Doubal… - Chinese medical …, 2021 - mednexus.org
Cerebral small vessel disease (SVD) is a common global brain disease that causes cognitive
impairment, ischemic or hemorrhagic stroke, problems with mobility, and neuropsychiatric …

Impact of small vessel disease progression on long-term cognitive and functional changes after stroke

U Clancy, SDJ Makin, CA McHutchison, V Cvoro… - Neurology, 2022 - AAN Enterprises
Background and Objectives The severity of white matter hyperintensities (WMH) at presentation
with stroke is associated with poststroke dementia and dependency. However, WMH can …

[HTML][HTML] Sex differences in cerebral small vessel disease: a systematic review and meta-analysis

L Jiménez-Sánchez, OKL Hamilton, U Clancy… - Frontiers in …, 2021 - frontiersin.org
Background: Cerebral small vessel disease (SVD) is a common cause of stroke, mild cognitive
impairment, dementia and physical impairments. Differences in SVD incidence or severity …

Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non …

…, G Blair, W Whiteley, S Shenkin, U Clancy… - The Lancet …, 2021 - thelancet.com
Background Oral anticoagulation reduces the rate of systemic embolism for patients with
atrial fibrillation by two-thirds, but its benefits for patients with previous intracranial …

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild …

U Clancy, DJ Garcia, MS Stringer… - European stroke …, 2021 - journals.sagepub.com
Background Cerebral small vessel disease is a major cause of dementia and stroke, visible
on brain magnetic resonance imaging. Recent data suggest that small vessel disease …

Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage

…, M Stringer, B Dickie, U Clancy… - Magnetic …, 2021 - Wiley Online Library
Purpose Dynamic contrast‐enhanced (DCE) ‐MRI with Patlak model analysis is increasingly
used to quantify low‐level blood‐brain barrier (BBB) leakage in studies of pathophysiology. …

Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease

…, C Arteaga, D Jaime Garcia, U Clancy… - Journal of Cerebral …, 2023 - journals.sagepub.com
Cerebral small vessel disease (SVD) is a cause of stroke and dementia. Retinal capillary
microvessels revealed by optical coherence tomography angiography (OCTA) are …

Imaging biomarkers of VCI: a focused update

U Clancy, AK Kancheva, MC Valdés Hernández… - Stroke, 2024 - Am Heart Assoc
Vascular cognitive impairment is common after stroke, in memory clinics, medicine for the
elderly services, and undiagnosed in the community. Vascular disease is said to be the …

Relationship between venules and perivascular spaces in sporadic small vessel diseases

…, GW Blair, MS Stringer, MJ Thrippleton, U Clancy… - Stroke, 2020 - Am Heart Assoc
Background and Purpose— Perivascular spaces (PVS) around venules may help drain
interstitial fluid from the brain. We examined relationships between suspected venules and PVS …